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KMID : 0358420160590040328
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Korean Journal of Obstetrics and Gynecology
2016 Volume.59 No. 4 p.328 ~ p.332
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A female adnexal tumor of probable Wolffian origin showing positive O-6-methylguanine-DNA methyltransferase methylation
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Kwon Min-Jung
Yun Min-Jeong
Kim Min-Kyu
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Abstract
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Female adnexal tumor of probable Wolffian origin (FATWO) is a rare disease entity that arises from the mesonephric duct system. FATWO is different than other gynecological cancers in terms of embryology. Here, we describe the case of a 52-year-old woman with malignant FATWO. The patient underwent explorative laparotomy and surgical staging after a frozen section revealed malignancy. Detailed examination of the pathologic findings were consistent with FATWO. Counseling and further testing were provided to the patient to assess the risk of germline mutation and epigenetic change. An O-6-methylguanine-DNA methyltransferase gene methylation test was positive, and all other tests were normal. This is the first study to report a case of O-6-methylguanine-DNA methyltransferase methylation with FATWO in Korea.
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KEYWORD
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Epigenesis, Genetic, O(6)-methylguanine-DNA methyltransferase methylation, Wolffian tumor
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